Discover novel functions of the polycomb group proteins ASXLs in epigenetic regulation

Topic description

Subject of the thesis: Biochemical and Functional Characterization of ASXLs and interacting partners: implications for chromatin-associated processes, cell cycle control and tumor suppression.

Our research delves into the complex mechanisms of epigenetic regulation, particularly in relation to Polycomb Group proteins. Central to our study are the ASXL proteins, key players in epigenetic regulation. Despite their significance, much remains to be discovered about how ASXL proteins contribute to epigenetic regulations and how their deregulation influences cancer and other diseases. By employing advanced genomics, bioinformatics, proteomics and mouse genetics methodologies, including CRISPR/Cas technology, we aim to uncover the roles and mechanisms of ASXL proteins in epigenetic regulation. For students who become part of our team, this project is a great learning opportunity at the forefront of Proteomics, Genomics, and cell signaling.